Effect of probiotic administration in the therapy of pediatric thermal burn.
نویسندگان
چکیده
Oral probiotic administration has been advocated for treatment and prevention of a diverse range of disorders. This study was undertaken to evaluate the effect of probiotic supplementation on outcome of pediatric post-burn patients. Forty thermally-injured pediatric patients with total body surface burns between 20-50% and depth between 5-10% were randomized in a prospective, double-blind, controlled clinical trial into two even groups: probiotic group (n=20), who received probiotic preparations, and placebo control group (n=20). Clinical outcomes, including GIT tolerance, incidence of infection, need for grafting, length of hospital stay and mortality were recorded. Laboratory measurements of serum CRP, serum albumin, serum IgA and total lymphocyte count were done upon admission and on days 4, 7 and 14. There were no significant differences between the groups regarding age (3.67 ± 0.67 vs. 3.56 ± 0.73), sex, %BSA (34.5 ± 1.96 vs. 33.9 ± 1.82) and %deep burns (6.95 ± 0.34 vs. 7.25 ± 0.39). Frequency of diarrhea (3 vs. 9), need for grafting (2 vs. 8) and length of hospital stay (17.25 ± 0.5 days vs. 21.9 ± 2.2 days) were significantly lower in the probiotic group (p=0.038, p=0.028 and p=0.044, respectively). A trend towards a decrease in incidence of infections (7 vs. 12) was noted in the probiotic group (p=0.113). There was no mortality in our series. There was improvement in the patients' overall outcome related to wound healing and length of hospital stay following the use of probiotics. However, their effects on infectious morbidity and mortality remain unclear and require further investigation.
منابع مشابه
Prophylactic oral probiotic on prevention of feeding intolerance in Very Low Birth Weight (VLBW) neonates: Randomized Clinical Trial
Background: Feeding intolerance is prevalent in very low birth weight (VLBW) neonates and is a barrier for better and faster growth in these neonates. Some studies have supported the administration of oral probiotic to decrease feeding intolerance. The aim of this study was to evaluate the effect of probiotic on feeding intolerance in VLBW neonates. Methods: This randomized clinical trial st...
متن کاملSynergistic Effect of Probiotic Bacteria and Antibiotics on Antibiotic-resistant Strains of Pseudomonas Aeruginosa Isolated from Patients with Burn Wounds
Background: Burn infections are one of the leading causes of death in the world. Antibiotic resistance is a major concern among the medical community. In this study, we investigated the effect of common probiotic strains on multidrug-resistant Pseudomonas aeruginosa strains. Methods: Strains of Pseudomonas aeruginosa from burn wounds of patients were isolated. Then pathogens were biochemically ...
متن کاملParenteral Albumin Therapy in Burn Patients: A Randomized Controlled Trial
Background: Administration of albumin for burn patients and its effects on mortality and morbidity has been debated for along time. The aim of this study was to evaluate the effects of albumin administration on wound healing, length of hospital stay, weight change, and mortality of burn patients. Methods: Two matched groups of patients from Shiraz Burn Care Center were randomly selected. The pa...
متن کاملThe effect of Aromatherapy on Pain, Itching, State Anxiety Levels and Respiratory Distress in Children with Burns: A Systematic Review
Background: Search of the literature reveals that there is no published systematic review on the effect of aromatherapy therapy on the pediatric and adolescent burns. For this reason, we conducted a systematic review to inspect the effects of massage therapy on reducing pain, itching, and anxiety levels in children with burns.</spa...
متن کاملInfluence of Probiotic bacteria on anemia in cancer patients undergoing chemotherapy and radiation therapy
Experimental evidence suggests that probiotics might have beneficial effect on the toxicity of anticancer therapy. In this study, the Double Blind Clinical trial was used to collect information and data. Participants were randomly divided into two experimental groups (probiotic) and a control group (placebo) after obtaining the consent of the company. At the start of the study, during a meeting...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of burns and fire disasters
دوره 29 4 شماره
صفحات -
تاریخ انتشار 2016